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基础医学系

林欣

履历

    1978-1982   上海科技大学,学士

    1982-1985   福建师范大学化学系,助教

    1985-1988   中国科学院北京研究生院,硕士研究生

    1988-1989   Baylor 医学院, 研究生 

    1989-1995   德克萨斯大学休斯敦医学院,博士

    1995-2000   加州大学旧金山分校,Gladstone Institutes, 博士后

    2000-2004   纽约州立大学布法罗分校医学院,微生物和免疫学系,助理教授

    2004-2009   德克萨斯大学安德森癌症中心,分子和细胞肿瘤学系,副教授 

    2009-2016   德克萨斯大学安德森癌症中心,分子和细胞肿瘤学系,终身教授

    2010-2016   德克萨斯大学安德森癌症中心,分子和细胞肿瘤学系,冠名讲席教授(United Resources Inc. Endowed Professorship)

    2008-2016   德克萨斯大学安德森癌症中心,炎症与癌症研究中心,副主任 

    2011-2014   德克萨斯大学生物医学研究生院,肿瘤生物学项目主任

    2009-2016   同济大学医学院,讲座教授(兼职) 

    2014-现在    清华大学医学院,教授,基础医学系主任 


研究领域与方向

固有免疫应答、淋巴细胞激活、肿瘤免疫治疗

我们实验室的研究兴趣涵盖免疫学的几个方面,前期主要研究转录因子NF-B活化过程的相关信号通路,探讨其在T淋巴细胞活化、炎症反应、以及肿瘤发生中的作用及其机理,系统地研究了T 淋巴细胞受体激活途径及调节T淋巴细胞激活的信号通路。近年来关注于固有免疫应答的相关信号通路研究,以及肿瘤免疫治疗的应用研究,共发表学术论文100多篇。

研究内容:

1.T淋巴细胞激活的调控机制

2.固有免疫应答的分子机制 

3.肿瘤的细胞免疫治疗研究

学术荣誉与奖励

    德克萨斯大学安德森癌症医院冠名讲席教授,2010

    德克萨斯大学安德森癌症医院学者奖,2008

    美洲华人生物科学学会(SCBA) 德克萨斯分会主席,2009

    美国白血病与淋巴瘤协会学者奖,2004

    美国Cancer Research Institute,研究者奖,2004


关键词

固有免疫应答、淋巴细胞激活、肿瘤免疫治疗

代表性论文

1.      Wang, D.; You, Y.; Case, S.M.; Wang, L.; DiStefano, P.S., Nunez, G.; Bertin, J.; Lin, X. (2002) A requirement of CARMA1 in T cell receptor-induced NF-kB activation. Nature Immunology. 3(9): 830-5.

2.      Wang, D.; Matsumoto, R.; You, Y.; Che, T.; Lin, X-Y; Gaffen, SL; Lin, X. (2004) CD3-CD28 costimulation-induced NF-kB activation is mediated by recruitment of PKC-q, Bcl10, and IKKb to the immunological synapse through CARMA1. Mol. Cell. Biol. 24 (1), 164-171.

3.      Che, T.; You, Y.; Wang, D.; Dixit, VM; Tanner, M.J.; Lin, X. (2004) MALT1/Paracaspase is a signaling component downstream of CARMA1 and mediates T cell receptor-induced NF-kB activation. J. Biol. Chem. 279, 15870-15876.

4.      Blonska, M.; You, Y.; Geleziunas, R. Lin, X. (2004) Restoration of NF-kB Activation by tumor necrosis factor-alpha receptor complex-targeted MEKK3 in Receptor-Interacting Protein-deficient cells. Mol. Cell. Biol. 24 (24), 10757-10765.

5.      Matsumoto, R.; Wang, D.; Blonska, M.; Li, H.; Kobayashi, M.; Pappu, B.; Chen, Y.; Wang, D.; Lin, X. (2005) Phosphorylation of CARMA1 plays a critical role in T cell receptor-induced NF-kB activation. Immunity, 23, 1-11, 2005.

6.      Blonska, M.; Shambharkar, P.B.; Kobayashi, M.; Zhang, D.; Sakurai, H.; Su, B.; Lin, X. (2005) TAK1 is recruited into TNFa receptor 1 complex through a RIP-dependent manner and cooperates with MEKK3 leading to NF-kB activation. J. Biol. Chem. 280 (52) 43056-43063, 2005.

7.      Li, H.; Kobayashi, M.; Blonska, M.; You, Y; Lin, X. (2006) Ubiquitination of RIP is required for TNFa-induced NF-kB activation. J. Biol. Chem. 281 (19) 13636-43.

8.      Pappu, B.; Lin, X. (2006) The role of CARMA1 in splenic B cell development and function. Eur. J. Immunol. 36 (11): 3033-43

9.      Wang, D.; You, Y.; Lin, P.; Xue, L.; Morris, S.; Zeng, H.; Wen, R., Lin, X. (2007) Bcl10 is required for G protein-coupled receptor-induced NF-kB activation. Proc. Natl. Acad. Sci. USA (Track II), 104(1): 145-50.

10.   Blonska, M.; Pappu, B.; Li, H.; Matsumoto R.; Su, B.; Wang, D.; Lin, X. (2007) The CARMA1-Bcl10 complex selectively regulates JNK2 in the T cell receptor signaling pathway. Immunity, 26(1): 55-66.

11.   Hsu, MY, Zhang, Y.; You, Y.; Wang, D.; Li, H.; Duramad, O, Qin, X; Dong, C; Lin, X. (2007) CARD9 is required for innate immune responses against intracellular pathogens. Nature Immunology, 8(2): 198-205.

12.   Shambharkar, P.B.; Blonska, M; Pappu, B.P.; Li, H.; You, Y.; Darnay, B.; Lin, X. (2007) Phosphorylation and ubiquitination of IKK complex by two distinct signaling pathways. EMBO J. 26(7): 1794-805.

13.   Grabiner, B.; Lin, P.; Blonska, M.; You, Y.; Wang, D.; Sun, J.; Darnay, BG; Dong, C.; Lin, X. (2007) CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-kB activation. GENES & DEVELPMENT. 21(8): 984-96

14.   Tanner, MJ; Hanel, W.; Gaffen, SL; Lin, X. (2007) CARMA1 Coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1, and is required for T cell receptor-induced NF-kB activation. J. Biol. Chem. 282 (23): 17141-7

15.   Sun J. and Lin X. (2008) b-arrestin 2 is required for lysophosphatidic acid-induced NF-kB activation. Proc. Natl. Acad. Sci. USA. Nov 4;105(44):17085-90.

16.   Wu W, Hsu YM, Bi L, Songyang Z, Lin X. (2009) CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex. Nature Immunology. Nov; 10(11):1208-14.

17.   Bi L, Gorjestani S, Wu W, Hsu YM, Zhu J, Ariizumi K, Lin X (2010) CARD9 mediates Dectin-2-induced IKK ubiquitination leading to activation of NF-kappaB in response to the stimulation by the hyphal form of Candida albicans. J. Biol. Chem. Aug 20; 285(34): 25969-77

18.   Jiang T, Grabiner B, Zhu Y, Jiang C, Li H, You Y, Lang J, Hung M-C, Lin X (2011) CARMA3 is crucial for EGF-induced activation of NF-kB and tumor progression. Cancer Research. Mar 15; 71(6):2183-92.

19.   Gorjestani S, Yu M, Tang B, D Zhang, Wang D, Lin X (2011) Phospholipase Cγ2 (PLCγ2) is a key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses. J. Biol. Chem. Dec 23; 285(51): 43651-43659

20.   Blonska M., Joo D, Zweidler-McKay PA, Zhao Q, Lin, X. (2012) CARMA1 controls Th2 cell-specific cytokine expression through regulating JunB and GATA3 transcription factors. J Immunol. Apr 1; 188(7): 3160-8. Epub 2012 Feb 27.

21.   Gorjestani S, Darnay B, Lin X (2012) TRAF6 and TAK1 play essential roles in C-type lectin receptor signaling in response to Candida albicans infection. J. Biol. Chem. 2012, Dec 28; 287(53): 44143-50.

22.   Liu XK, Li H, Zhong B, Blonska M, Gorjestani S, Yan M, Tian Q, Zhang D, Lin X*, Dong C* (2013). USP18 inhibits NF-kB and NFAT activation during Th17 differentiation by deubiquitinating TAK1/TAB1 complex. J. Exp. Med. 2013 Jul 29; 210(8): 1575-90.*Co-corresponding authors

23.   Zhu LL, Zhao XQ, Jiang CY, You Y, Chen XP, Jiang YY, Jia XM, Lin X (2013) C-type lectin receptors Dectin-3 (CLECSF8) and Dectin-2 form a heterodimeric pattern recognition receptor for host defense against fungal infection. Immunity, 2013 Aug 22; 39(2):324-34.

24.   Blonska M, Joo D, Nurieva RI, Zhao X, Chiao P, Sun S-C, Dong C, Lin X (2013) Activation of the Transcription Factor c-Maf in T Cells is Dependent on the CARMA1-IKKb Signaling Cascade. Science Signaling. Dec 17; 6(306): ra110. doi: 10.1126/scisignal.2004273.

25.   Jia XM, Tang B, Zhu LL, Liu YH, Zhao XQ, Gorjestani S, Hsu Y-M, Yang L, Guan JH, Xu GT, Lin X (2014) CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for anti-fungal immunity. J Exp Med. 2014 Oct 20;211(11):2307-21.

26.   Zhao XQ, Zhu L-L, Chang Q, Jiang C, Luo TM, You Y, Jia X-M, and Lin X. (2014). C-type lectin Dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent NF-?B activation. J Biol Chem. 2014 Oct 24; 289(43):30052-62

27.   Blonska M, Zhu Y, Chuang H, You, JM, Kunkulla K, Vega F, Lin X (2015). Jun-regulated genes promote interaction of diffuse large B-cell lymphoma with the microenvironment. Blood 2015 Feb 5;125(6):981-91.

28.   Pan D, Jiang C, Ma Z, Blonska M, James You MJ, and Lin X (2015) MALT1 is required for EGFR induced NF-kB activation and contributes to EGFR-driven lung cancer progression. Oncogene. 2015 May 18. doi: 10.1038/onc.2015.146. [Epub ahead of print]

29.   Pan D, Zhu Y, Zhou Z, Wang T, You H, Jiang C, Lin X. (2016) The CBM Complex Underwrites NF-kappaB Activation to Promote HER2-associated Tumor Malignancy. Mol Cancer Res. 2016 Jan;14(1):93-102.

30.   Jiang C, Zhou Z, Quan Y, Zhang S, Wang T, Zhao X, Morrison C, Heise MT, He W, Miller MS, and Lin X. (2016) CARMA3 is a host factor regulating the balance of inflammatory and antiviral responses against viral infection. Cell Reports. 2016 Mar 15;14(10):2389-401.

31.   Wang T, Pan, D, Zhou Z, Jiang C, You Y, and Lin X (2016) Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut. PLOS Pathogens 2016 Jun 9;12 (6): e1005662. doi: 10.1371/journal.ppat.1005662. eCollection 2016 Jun.

32.   Zhu LL, Luo TM, Xu X, Guo YH, Zhao XQ, Tang B, Jiang YY, Lin X*, Jia XM* (2016) E3-ubiquitin-ligase Cbl-b negatively regulates C-type lectin receptor-mediated anti-fungal innate immunity. J Exp Med, 2016 Jul 25;213(8):1555-70. *Co-corresponding author

33.   Joo D, Tang Y, Blonska M, Jin J, Zhao X, Lin X. (2016) Regulation of linear ubiquitin chain assembly complex by Caspase-mediated cleavage of RNF31. Mol Cell Biol. 2016 Sep 26. pii: MCB.00474-16. [Epub ahead of print]

34.   Jiang C, Zhu Y, Zhou Z, Gumin J, Bengtsson L, Wu W, Songyang Z, Lang FF, Lin X (2016) TMEM43/LUMA is a key signaling component mediating EGFR-induced NF-kB activation and tumor progression. Oncogene, 2016 Dec 19. doi: 10.1038/onc.2016.430. [Epub ahead of print]

35.   Zhao X, Guo Y, Jiang C, Chang Q, Zhang S, Luo T, Zhang B, Jia X, Hung MC, Dong C, Lin X (2017) JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression. Nature Medicine. 2017 Mar;23(3):337-346. doi: 10.1038/nm.4260. Epub 2017 Jan 23.

36.   Zhang S, Pan D, Jia XM, Lin X*, Zhao X*. (2017). The CARMA3-BCL10-MALT1 (CBM) complex contributes to DNA damage-induced NF-κB activation and cell survival. Protein & Cell. 2017 Jul 17. doi: 10.1007/s13238-017-0441-3. [Epub ahead of print].*Co-corresponding authors

37.   Tang Y, Tu H, Liu G, Zheng G, Wang M, Li L, Zhao X, and Lin X. (2018). RNF31 regulates skin homeostasis by protecting epidermal keratinocytes from cell death. J Immunol. 2018 Jun 15;200(12):4117-4124

38.   Xu X, Xu J, Zheng G, Lu H, Rui W, Guan J, Cheng L, Yang D, Wang M, Duan J, Lv Q, Li J, Zhao X, Chen C, Shi P, Jia X*, Lin X*. (2018). CARD9S12N mutation converts alveolar macrophages into IL-5-producing cells and facilitates type 2 immune responses. Nature Immunology, 2018 Jun;19(6):547-560.

39.   Wang M, Zhang S, Zheng G, Huang J, Songyang Z, Zhao X, Lin X. (2018). Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A. Immunity. 2018 Jul 17;49(1):66-79

40.   Zheng G, Jiang C, Yang D, Li Y, Ma Y, Zhang B, Li X, Zhang P, Hu X, Zhao X, Du J, Lin X. (2018). TMEM43-S358L mutation enhances NF-kB-TGFb signal cascade and PPARg pathway in arrhythmogenic right ventricular dysplasia/cardiomyopathy. Protein & Cells 2018 Jul 6. doi: 10.1007/s13238-018-0563-2. [Epub ahead of print]

41.   Wang T, Fan C, Yao A, Xu X, Zheng G, You Y, Jiang C, Zhao X, Hung MC, Lin X. (2018). The adaptor protein CARD9 protects against colitis-associated colon cancer by restricting mycobiota-mediated expansion of myeloid-derived suppressor cells. Immunity, 2018 Sep 18;49(3):504-514

42.   Guo Y, Chang Q, Cheng L, Xiong S, Jia X, Lin X*, Zhao X*. (2018). C-type lectin receptor CD23 controls antifungal immunity through regulating nitric oxide production in activated macrophages. J Immunol. 2018 Oct 15;201(8):2427-2440*Co-corresponding authors

43.   Tang Y, Joo D, Liu G, Tu H, You J, Jin J, Zhao X, Hung M, Lin X. (2018). Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFa-induced apoptosis. J Biol Chem. 2018 Dec 28;293(52):20062-20072


联系方式

Email: linxin307 at tsinghua.edu.cn

Phone: 86-10-62796319 (office); 86-10-62794262 (lab)

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