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基础医学系

刘锦涛

履历

    2017-至今  研究员,博士生导师,清华大学医学院基础医学系

    2012-2017 博士后,美国加州大学圣地亚哥分校生物科学部

    2011-2012 博士后,美国匹兹堡大学计算与系统生物系

    2004-2011 博士(物理),美国匹兹堡大学

    2000-2004 学士(物理),中国科学技术大学


研究领域与方向

刘锦涛课题组主要从事细菌生物被膜(bacterial biofilm)方面的研究。菌膜是由紧密排列的细菌形成的群落。它们导致许多病菌感染,并对药物及人体免疫系统有超强的抵抗力,这为治疗细菌感染提出了很大的挑战。本课题组使用交叉学科及定量的研究方法,致力于开发创新的菌膜培养及观测技术,研究菌膜的群体行为及时空动态特性,并寻找治疗细菌感染的有效途径。

学术荣誉与奖励

    求是杰出青年学者(2018)


关键词

Bacterial community, biofilm resistance, collective dynamics, microfluidics.

代表性论文

1.Martinez-Corral R, Liu J, Süel GM, Garcia-Ojalvo J. Bistable emergence of oscillations in growing Bacillus subtilis biofilms. PNAS 115, E8333 (2018).

2.Larkin JW, Zhai X, Kikuchi K, Redford SE, Prindle A, Liu J, Greenfield S, Walczak AM, Garcia-Ojalvo J, Mugler A, Süel GM. Signal Percolation within a Bacterial Community. Cell Systems 7, 137 (2018).

3.Lee DD, Prindle A, Liu J, Süel GM. Snapshot: Electrochemical Communication in Biofilms. Cell 170, 214 (2017).

4.Liu J, Martinez-Corral R, Prindle A, Lee DD, Larkin J, Gabalda-Sagarra M, Garcia-Ojalvo J, Süel GM. Coupling between distant biofilms and emergence of nutrient time-sharing. Science 356, 638 (2017).

5.Humphries J, Xiong L, Liu J, Prindle A, Yuan F, Tsimring L, Su?el GM. Species-independent attraction to biofilms through electrical signaling. Cell 168, 200 (2017).

6.Mugler A, Kittisopikul M, Hayden L, Liu J, Wiggins CH, Su?el GM, Walczak AM. Noise expands the response range of the Bacillus subtilis competence circuit. PLoS Computational Biology 12(3): e1004793 (2016).

7.Prindle A, Liu J, Asally M, Ly S, Garcia-Ojalvo J, Su?el GM. Ion channels enable electrical communication in bacterial communities. Nature 527, 59 (2015).

8.Liu J, Prindle A, Humphries J, Gabalda-Sagarra M, Asally M, Lee DD, Ly S, Garcia-Ojalvo J, Su?el GM. Metabolic co-dependence gives rise to collective oscillations within biofilms. Nature 523, 550 (2015).

9.Setlow P, Liu J, Faeder JR. Heterogeneity in bacterial spore populations. In Bacterial Spores: Current Research and Applications. Editor: Ernesto Abel-Santos. Caister Academic Press (2012).

10.Yi X*, Liu J*, Faeder JR, Setlow P. Synergism between different germinant receptors in the germination of Bacillus subtilis spores. Journal of Bacteriology 193, 4664 (2011). (* co-first author)

11.Liu J, Faeder JR, Camacho CJ. Toward a quantitative theory of intrinsically disordered proteins and their function. Proceedings of the National Academy of Sciences USA 106, 19819 (2009).

12.Goldschmidt YY, Liu J. Langevin dynamics of the two-stage melting transition of vortex matter in Bi2Sr2CaCu2O8 in the presence of straight or tilted columnar defects. Physical Review B 76, 174508 (2007).

13.Avraham N, Goldschmidt YY, Liu J, Myasoedov Y, Rappaport M, Zeldov E, van der Beek CJ, Konczykowski M, Tamegai T. Dynamic and thermodynamic properties of porous vortex matter in Bi2Sr2CaCu2O8 in an oblique magnetic field. Physical Review Letters 99, 087001 (2007).

14.Qing Chen, Yi Wang, Liu J, Ke-Lin Wang. N-player quantum minority game. Physics Letters A 327, 98 (2004).



联系方式

Email: JintaoLiu at tsinghua.edu.cn

Phone: 010-62791229

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