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基础医学系

丁强

履历

    2018-至今: 清华大学助理教授(tenure-track assistant professor)
    2014-2018:美国普林斯顿大学(Princeton University), 博士后
    2007-2013:中国科学院上海巴斯德研究所,博士
    2003-2007:西南师范大学,学士


研究领域与方向

本课题组主要以对人类公共健康产生严重威胁的肝炎病毒以及黄病毒为主要研究对象,运用分子生物学,反向遗传学,基因组以及蛋白质组学手段,阐述病毒的生活周期,鉴定对病毒感染必需的宿主因子以及限制病毒感染的抗病毒因子。从分子水平上研究病毒种属感染以及器官感染特异性的机制,从而为抗病毒药物开发,传染病防治以及实验动物模型开发提供理论基础。

具体研究内容包括:

1. 肝炎病毒以及黄病毒感染的分子基。?⑾旨?ú《靖腥颈匦氲乃拗饕蜃踊蛘呦拗菩砸蜃樱狐/span>

2. 寻找决定病毒感染种属特异性的宿主因子;

3. 在理解病毒和宿主相互作用的基础上,开发支持病毒感染的动物模型,为新药和疫苗开发提供有力的工具。


学术荣誉与奖励

    2017   美国病毒学学会博士后旅行奖(American Society for Virology 2017 Postdoctoral Fellow Travel Award)

    2016   新泽西癌症研究学会博士后奖(Postdoctoral Award of New Jersey Commission on Cancer Research)

    2014   第21届HCV年会博士后旅行奖(Travel award to attend 21st International Symposium on HCV and Related Viruses)

    2014   中国科学院优秀博士论文奖

    2013   中国科学院院长优秀奖


关键词

病毒性肝炎, 黄病毒, 抗病毒免疫,分子病毒学

代表性论文

1.  Tao, W., Xu, C., Ding, Q., Li, R., Xiang, Y., Chung, J. and Zhong, J., A single point mutation in E2 enhances hepatitis C virus infectivity and alters lipoprotein association of viral particles. Virology 395: 67-76 (2009)

2.  Ding, Q., Huang, B., Lu, J., Liu, Y-J. and Zhong, J., Hepatitis C virus NS3-4A protease blocks IL28 production. European Journal of Immunology 42:2374-2382 (2012)

3.  Ding, Q.*, Cao, X.*, Lu, J., Huang,B., Liu, Y-J., Kato, N., Shu H-B., and Zhong, J., Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity. Journal of Hepatology 59:52-58 (2013)

4.  Cao, X.*, Ding, Q.*, Lu, J., Huang, B., Zhao, Y., Niu, J., Liu, YJ., and Zhong, J. MDA5 plays a critical role in interferon response during hepatitis C virus infection. Journal of Hepatology 62: 771-778 (2015) (C.X. and Q.D. are co-fist authors)

5.   von Schaewen, M., Ding, Q., and Ploss, A. Visualizing Hepatitis C virus infection in humanized mice. J Immunol Methods 410: 50-59 (2014)

6.  Ding, Q., von Schaewen, M., and Ploss, A. The impact of hepatitis C virus entry on viral tropism. Cell Host & Microbe 16: 562-568 (2014)

7.  Douam, F, Gaska, JM, Winer, BY, Ding, Q, von Schaewen, M, and Ploss, A. Genetic Dissection of the Host Tropism of Human-Tropic Pathogens. Annual Review of Genetics 49, 21-45 (2015)

8.  Douam, F. *, Ding, Q. *, and Ploss, A. Recent advances in understanding hepatitis C. F1000Research 2016. 5 (F1000 Faculty  Rev):131 (D.F. and Q.D. are co-first  authors)

9.  Winer, B., Ding, Q., Gaska, J., and Ploss, A. In vivo models of hepatitis B and C virus infection. FEBS Letter doi:10.1002/1873-3468.12157 (2016)

10. Ding, Q., von Schaewen M., Hrebikova, G., Heller, B., Sandmann, L., Plaas, M., and Ploss, A. Mice expressing minimally humanized CD81 and occludin genes support hepatitis C virus uptake in vivo. Journal of Virology 91:e01799-16 (2017)

11. Ding, Q., Heller, B., Capuccino, J MV., Song, B., Nimgaonkar, I., Hrebikova, G., Contreras, J., and Ploss, A. Hepatitis E virus ORF3 is a functional ion channel required for release of infectious particles. Proc Natl Acad Sci U S A 114(5): 1147-1152 (2017)

12.  Douam, F., Hrebikova,G., Albrecht, Y., Sellau, J., Sharon,Y., Ding, Q., and Ploss, A. Single-cell tracking of flavivirus RNA uncovers species-specific interactions with the immune system dictating disease outcome. Nature Communication 8:14781 (2017)

13.  Nimagaonkar, I., Ding, Q. Schwartz, R., and Ploss, A. Hepatitis E: advances and challenges. Nature Reviews Gastroenterology & Hepatology 15, 96–110 (2018)

14. Douam, F., Fusil. F., Enguehard, M., Dib.L., Nadalin.F., Schwaller.L., Hrebikova. G., Mancip, J., Mailly. L., Montserret. R., Ding, Q., Maisse. C., Carlot. E., Verhoeyen.E., Baumert. T., Ploss A., Carbone A., Cosset.F., and Lavillette.D. A protein coevolution method uncovers critical features of the Hepatitis C Virus fusion mechanism. PLoS pathogens 14 (3), e1006908 (2018)

 15. Liang, Y*., Cao, X*., Ding, Q., Zhao, Y., He, Z., and Zhong, J. HCV NS4B induces the degradation of TRIF to inhibit TLR3 mediated interferon signaling pathway. PLoS pathogens 14 (5), e1007075 (2018)

16. Ding, Q. Nimagaonkar, I., Bron, Y., Heller, B., Schwartz, R., and Ploss, A. Identification of the intragenomic promoter controlling hepatitis E virus subgenomic RNA transcription. mBio 9 (3), e00769-18 (2018)

17. Ding, Q. Graemespacher, J., Winer, B., Heller, B., Douam, F., Wei, L., Muir,T. and Ploss, A. Species-specific disruption of antiviral cellular defenses by the Zika virus NS2B3 protease. Proc Natl Acad Sci U S A  115(27):E6310-E6318 (2018)

18. Gaska, J., Ding, Q., and Ploss, A. Mouse models for studying HCV vaccines and therapeutic antibodies. Methods in Molecular Biology (2017). In Press

19. Bron, Y., Ding, Q., Douam, F., Moscona., A., Porotto, M., Ploss, A., and Schwartz, R. Multiplexed detection of viral DNAs, RNAs and proteins in single cells. 2018 Submit

* These authors contributed equally.


联系方式

Email: qding at tsinghua.edu.cn

Phone:

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