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基础医学系

娄智勇

履历

    2010- 至今 清华大学医学院 研究员
    2007-2010 清华大学医学院 助理研究员
    2002-2007 清华大学医学院 博士
    1998-2002 清华大学基础科学班 学士

研究领域与方向

主要针对高致病性 RNA 病毒,发现病毒感染和入侵的新型受体,研究病毒侵染、复制中关键蛋白 质的结构与功能,阐明病毒侵染和复制的分子机制,揭示宿主细胞与病原体的相互关系,并以此 为基础开展抗病毒药物的研究工作

1. The molecular mechanism of virus entry

2. The molecular mechanism of viral replication and transcription

3. The molecular mechanism of virus assembly

4. Antivirals



学术荣誉与奖励

关键词

antiviral, replication and transcription, virus

代表性论文

1.       Bunyamwera virus possesses a distinct nucleocapsid protein to facilitate genome encapsidation. Li B., Wang Q., Pan X., Fernández de Castro, I., Sun Y., Guo Y., Tao X., Risco C., Sui S.F. and Lou Z.* Proc Natl Acad Sci USA

2.       Crimean-Congo hemorrhagic fever virus nucleoprotein reveals an endonuclease activity in the Bunyaviruses. Guo Y., Wang W., Ji W., Deng M., Sun Y., Zhou H., Yang C., Deng F., Wang H., Hu Z.*, Lou Z.* and Rao Z*. Proc Natl Acad Sci USA 2012 Mar 27;109(13):5046-51.

3.       Structural basis of a histone H3 lysine 4 demethylase required for stem elongation in rice. Chen Q, Chen X, Wang Q, Zhang F, Lou Z*, Zhang Q*, Zhou DX*. PLoS Genet. 2013 Jan;9(1):e1003239.

4.       Enterovirus 71 VPg uridylation uses a two-molecular mechanism of 3D polymerase. Sun Y., Wang Y., Shan C., Chen C., Xu P., Song M., Zhou H., Yang C., Xu W., Shi P.Y., Zhang B., Lou Z.*. J Virol. 2012 Dec;86(24):13662-71.

5.       Crystal structure of EV71 RNA-dependent RNA polymerase complexed with its protein primer VPg: Implication for a trans mechanism of VPg uridylylation. Chen C., Wang Y., Shan C., Sun Y., Xu P., Zhou H., Yang C., Shi P.Y., Rao Z., Zhang B.* and Lou Z.*. J Virol.

6.       Crystal Structure of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis. Shan S., Chen X., Liu T., Zhao H., Rao Z. and Lou Z.*. FASEB J. 2011 Jan 31.

7.       Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Yuan P.$, Bartlam M.$, Lou Z.$, Chen S., Zhou J., He X., Lv Z., Ge R., Li X., Deng T., Fodor E., Rao Z. and Liu Y. Nature. 2009 Apr 16; 458(7240):909-13.

8.       The crystal structure of porcine reproductive and respiratory syndrome virus nonstructural protein Nsp1beta reveals a novel metal-dependent nuclease. Xue F., Sun Y., Yan L., Zhao C., Chen J., Bartlam M., Li X., Lou Z.*, Rao Z. J Virol. 2010 Jul;84(13):6461-71.

9.       Crystal Structure of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Leader Protease Nsp1α. Sun Y., Xue F., Guo Y., Ma M., Hao N., Zhang X.C., Lou Z.*, Li X., Rao Z. J Virol. 2009 Nov;83(21):10931-40.


联系方式

Email: louzy at mail.tsinghua.edu.cn

Phone: +86-10-62771493