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基础医学系

王大亮

履历

    2015.12-至今   清华大学医学院,基础医学系,副教授
                           美国匹兹堡大学医学院,访问学者
    2012-2015     清华大学医学院,基础医学系,讲师
    2008-2012     清华大学医学院,表观遗传学与癌症研究室,助研
    2007-2008     日本东京大学医学院,分子生物学,博士后
    2002-2007     日本东京大学医学院,分子生物学,博士
    1998-2001     首都医科大学,病理与病理生理学专业,硕士
    1994-1998     首都医科大学附属北京妇产医院,病理科,医师
    1989-1994     大连医科大学,临床医学专业,学士



研究领域与方向

研究领域:肿瘤的表观遗传调控

教学:组织学、病理学等课程


学术荣誉与奖励

关键词

癌基因,表观遗传调控,干细胞分化、重编程

代表性论文

1.Zhang Y, Chang JF, Sun J, Chen L, Yang XM, Tang HY, Jing YY, Kang X, He ZM, Wu JY, Wei HM, Wang DL, Xu RG, Zhu RB, Shen Y, Zeng SY, Wang C, Liu KN, Zhang Y, Mao ZY, Jiang CZ, Sun FL*. Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability. J Cell Sci. 2018 Jun 21;131(12).

2. Gao YChen MWu JZhou YCai CWang D*, Luo J*,Facilitating in vivo tumor detection by principal component analysis based on dynamic fluorescence molecular imaging. Journal of Biomedical Optics. 2017 Sep; 22(9):1-9. *Corresponding author.

3.Wu J, He Z, Yang XM, Li KL, Wang DL*, Sun FL*. RCCD1 depletion attenuates TGF-β-induced EMT and cell migration by stabilizing cytoskeletal microtubules in NSCLC cells. Cancer Lett. 2017 Aug 1;400:18-29. *Corresponding author.

4. Wu J, He Z, Wang DL*, Sun FL*. Depletion of JMJD5 sensitizes tumor cells to microtubule-destabilizing agents by altering microtubule stability. Cell Cycle. 2016 Nov;15 (21):2980-2991. Oct 7:0. [Epub ahead of print]. Corresponding author.

5. Chen S, Jing Y, Kang X, Yang L, Wang DL, Zhang W, Zhang L, Chen P, Chang JF, Yang XM, Sun FL. Histone H2B monoubiquitination is a critical epigenetic switch for the regulation of autophagy. Nucleic Acids Res. 2016 Oct 26. pii: gkw1025. [Epub ahead of print].

6. He Z, Wu J, Su X, Zhang Y, Pan L, Wei H, Fang Q, Li H, Wang DL*, Sun FL*. Jumonji Domain Containing 5 (JMJD5) Associates with Spindle Microtubules and Is Required for Proper Mitosis. JBC, 2015 Feb 26; 291(9):4684-97. Corresponding author.

7. Pan L, Xie W, Li KL, Yang Z, Xu J, Zhang W, Liu LP, Ren X, He Z, Wu J, Sun J, Wei HM, Wang D, Xie W, Li W, Ni JQ, Sun FL*. Heterochromatin remodeling by CDK12 contributes to learning in Drosophila. PNAS 2015, 112(45):13988-93

8. Wang C, Chang JF, Yan H, Wang DL, Liu Y, Jing Y, Zhang M, Men YL, Lu D, Yang XM, Chen S, Sun FL*. A Conserved RAD6-MDM2 Ubiquitin Ligase Machinery Targets Histone Chaperone ASF1A in Tumorigenesis. Oncotarget. 2015 , 6(30):29599-613.

9. Chen S, Wang C, Sun L, Wang DL, Chen L, Huang Z, Yang Q, Gao J, Yang XB, Chang JF, Chen P, Lan L, Mao ZY, Sun FL. RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1. Mol Cell Biol. 2015 Jan 15;35(2):406-16.

10. Liu Y, Wang DL, Chang JF, Chen S, Sun FL, Long YH, Wang SQ, Li YF, Liu YK, Zhang JH. WSTF Phosphorylation Specifically Links H3K9ac with H4K16ac through PCAF/WSTF/MOF Complex. 2015. J Biol Chem. 2015 Apr 2. pii: jbc.M114.627927

11. Kanai Y, Wang D, Hirokawa N. KIF13B enhances the endocytosis of LRP1 by recruiting LRP1 to caveolae. J Cell Biol. 2014, 204(3): 395-408. 

12. Zhao L, Gu H, Chang J,  Wu J, Wang D, Chen S, Yang X, Qian B. MicroRNA-383 Regulates the Apoptosis of Tumor Cells through Targeting Gadd45g. PLoS One. 2014 Nov 21;9(11).

13. Zhao L, Wang DL, Liu Y, Chen S, Sun FL. Histone acetyltransferase hMOF promotes S phase entry and tumorigenesis in lung cancer. Cell Signal. 2013. 25(8): 1689-98.

14. Chen S*, Li J*, Wang DL*, Sun FL. Histone H2B lysine 120 monoubiquitination is required for embryonic stem cell differentiation. Cell Research. 2012. 22(9):1402-5. (IF: 11.3) * Co-first authors 

15. Liu Y, Wang DL, Chen S, Zhao L and Sun FL. Oncogene Ras/PI3K signaling targets histone H3 acetylation at lysine K56 in tumorigenesis. J Biol Chem. 2012. 30;287(49):41469-80.

16. Chen S, Wang DL, Liu Y, Zhao L, Sun FL*. RAD6 regulates the dosage of p53 by a combination of transcriptional and posttranscriptional mechanism. Mol Cell Biol. 2012 Jan; 32(2):576-87.

17. Lv WW, Wei HM, Wang DL, Ni JQ and Sun FL. Depletion of histone deacetylase 3 antagonizes PI3K-mediated tissue overgrowth through the acetylation of histone H4 at lysine 16. Journal of Cell Science. 2012 15;125 (Pt 22): 5369-78.

18. Chen S, Wei HM, Lv WW, Wang DL, Sun FL*. E2 ligase dRad6 regulates DMP53 turnover in Drosophila. J Biol Chem. 2011 Mar 18; 286 (11):9020-30. 

19. Zhang D, Wang D, Sun F*. Drosophila melanogaster heterochromatin protein HP1b plays important roles in transcriptional activation and development. Chromosoma. 2011 Feb;120(1):97-108. Epub 2010 Sep 21.


联系方式

Email: wangdaliang at tsinghua.edu.cn

Phone: +86-10-62792344

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